Why MycoSecMycobacterium are aerobic, unicellular, non motile (except M.marinum ), gram +ve bacteria with high G+C content belongs to family Mycobacteriaceae. The members of this family are very pathogenic causing serious diseases. Mycobacterium is cosmopolitian in distribution found in water and food sourses. They are not free living organisms but they are mostly obligate parasite.
Mycobacterial infections are notoriously difficult to treat. The organisms are hardy due to their cell wall, which is neither truly Gram negative nor positive. Additionally, they are naturally resistant to a number of antibiotics that disrupt cell-wall biosynthesis, such as penicillin. Due to their unique cell wall, they can survive long exposure to acids, alkalis, detergents, oxidative bursts, lysis by complement, and many antibiotics. Most mycobacteria are susceptible to the antibiotics clarithromycin and rifamycin, but antibiotic-resistant strains have emerged. As with other bacterial pathogens, surface and secreted proteins of M. tuberculosis contribute significantly to the virulence of this organism. Mycobacteria can be classified into several major groups for purpose of diagnosis and treatment: M. tuberculosis complex, which can cause tuberculosis: M. tuberculosis, M. bovis, M. africanum, and M. microti; M. leprae, which causes Hansen's disease or leprosy; Nontuberculous mycobacteria (NTM) are all the other mycobacteria, which can cause pulmonary disease resembling tuberculosis, lymphadenitis, skin disease, or disseminated disease.
Proteins are considered to be secreted when an N-terminal signal peptide existed but neither a transmembrane domain (except one within the first 40 residues), nor a GPI-anchor, nor any localization signal to other organelles are identified. Secreted proteins represent a distinct group of proteins with respect to their structure and function and contribution to virulence. They are of particular importance for vaccine development because they are often immunogenic and have the potential to be recognized early infection.
In future this work will definitely help others to study various others aspects of Mycobacterium like in studying
About virulence, pathogen infection and host-pathogen interactions.
Help in studying localisation of proteins.
Generation and characterization of new recombinant vaccines containing immunodominant antigens can be done by comparing the secretomes .
Knowledge of the host cell response to pathogenic microrganism is important to understand the disease process.
Studying global changes in bacterial gene expression is crucial for understanding the pathogenesis processes - microrganism ability to survive in the host and their interaction in the eukaryotic cell.The ability of all the datas which we have provided by using various server allow the study of comprative trancriptomics.
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